Thermo Fisher Scientific MZB1 Polyclonal Antibody
Thermo Fisher Scientific의 MZB1 Polyclonal Antibody는 인간 MZB1 단백질을 인식하는 Rabbit IgG 항체로, WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보존되어 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MZB1. Recombinant protein control fragment (Product #RP-100226) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644405 |
Product Specific Information
Immunogen sequence:
YGVREVDQVK RLTGPGLSEG PEPSISVMVT GGPWPTRLSR TCLHYLGEFG EDQIYEAHQQ GRGALEALLC GGPQGACSEK VSATR
Highest antigen sequence identity to orthologs:
- Mouse: 73%
- Rat: 74%
Target Information
MZB1 associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. It may act as a molecular chaperone or oxidoreductase, displaying low oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis.
MZB1 helps diversify peripheral B-cell functions by regulating Ca²⁺ stores, antibody secretion, and integrin activation.
Additionally, it acts as a hormone-regulated adipokine/proinflammatory cytokine implicated in chronic inflammation, affecting cellular expansion and insulin response in adipocytes, potentially contributing to insulin resistance.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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