Thermo Fisher Scientific CREBL2 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
REELEMYKQW CMAMDQGKIP SEIKALLTGE EQNKSQQNSS RHTKAGKTDA NSNSW

Highest antigen sequence identity to orthologs:

• Mouse: 85%
• Rat: 93%

Target Information

cAMP response element-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung, and ovarian cancers.
CREBL2 shares a 41% identity with CRE-binding protein over a 48-base long region encoding the bZip domain of CREB.
The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization.
This suggests that CREBL2 encodes a protein with DNA binding capabilities.
The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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