Thermo Fisher Scientific CREBL2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CREBL2 recombinant protein. Provides high specificity for research use in cancer and gene expression studies. Supplied as liquid, unconjugated form; store at 4°C short term or -20°C long term. RRID: AB_2640149.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CREBL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640149 |
Product Specific Information
Immunogen sequence:
REELEMYKQW CMAMDQGKIP SEIKALLTGE EQNKSQQNSS RHTKAGKTDA NSNSW
Highest antigen sequence identity to orthologs:
- Mouse: 85%
- Rat: 93%
Target Information
cAMP response element-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung, and ovarian cancers.
CREBL2 shares a 41% identity with CRE-binding protein over a 48-base long region encoding the bZip domain of CREB.
The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization.
This suggests that CREBL2 encodes a protein with DNA binding capabilities.
The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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