Thermo Fisher Scientific Human CUEDC2 Synthetic Peptide
인간 CUEDC2 단백질의 C-말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20620의 블로킹 펩타이드로 사용 가능. PBS 완충액 내 0.1% BSA 및 0.02% sodium azide 포함. -20°C에서 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of human CUEDC2.
PEP-0740 can be used as a blocking peptide with polyclonal antibody PA5-20620.
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases PR sumoylation and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by inhibiting IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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