Thermo Fisher Scientific Human BRAF, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Do not store kinase diluted.
If properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Protein Form: Full Length

Target Information

BRAF is involved in transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutations in human cancer and plays a role in postsynaptic responses of hippocampal neurons.
This protein regulates the MAP kinase/ERKs signaling pathway, affecting cell division, differentiation, and secretion.
Mutations in B-Raf are associated with various cancers, including:

• Non-Hodgkin lymphoma
• Colorectal cancer
• Malignant melanoma
• Thyroid carcinoma
• Non-small cell lung carcinoma
• Adenocarcinoma of lung

A pseudogene located on chromosome X has been identified for B-Raf.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.