Thermo Fisher Scientific Human CDK9/Cyclin T1, His Tag Recombinant Protein

Thermo Fisher Scientific Human CDK9/Cyclin T1, His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of the 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
• For larger sizes, prepare aliquots to reduce freeze/thaw cycles (aliquots below 20 µL not recommended).
• Do not store kinase diluted.
• Properly stored at -80°C, the product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Full Length

Target Information

CDK9 is a serine/threonine kinase that, when complexed with Cyclin T1, forms an active holoenzyme complex regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with Cyclin T1. It regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors and promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also exhibits kinase activity toward CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 can lead to cardiac myocyte enlargement and cardiac hypertrophy, predisposing to heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.