Thermo Fisher Scientific Human STK4 (MST1), GST Tag Recombinant Protein

Thermo Fisher Scientific Human STK4 (MST1), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquoting may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
• Do not store kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Full Length

Target Information

STK4 (MST1) is a serine/threonine kinase involved in apoptosis and chromatin condensation. It acts as a stress-activated, pro-apoptotic kinase that, following caspase cleavage, enters the nucleus and induces chromatin condensation and DNA fragmentation. STK4 is a key component of the Hippo signaling pathway, regulating organ size and tumor suppression by controlling cell proliferation and apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, together with SAV1, phosphorylate and activate LATS1/2 and MOB1, which in turn phosphorylate and inactivate YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, thereby regulating genes related to proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.