Thermo Fisher Scientific CD95 Polyclonal Antibody
Rabbit polyclonal antibody against human CD95 (FAS) for IHC (Paraffin) applications. Recognizes C-terminal peptide of CD95. Unconjugated, purified by antigen affinity chromatography. Suitable for apoptosis-related research in human tissues.
- 카탈로그번호
- 500-2504
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of human CD95 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human tonsil tissue
- Cellular location: Secreted and cell membrane
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein acting as a cell death receptor within the TNFR superfamily. A soluble form (~26 kDa) also exists. Activation of FAS leads to aggregation of FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and subsequent caspase activation, resulting in apoptosis.
FAS signaling can activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK pathways, influencing proliferation in fibroblasts and T cells. Multiple alternatively spliced transcript variants encode distinct isoforms, with soluble forms potentially inhibiting full-length FAS-mediated apoptosis.
The Fas/Fas ligand system is implicated in various human diseases, including AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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