Thermo Fisher Scientific Human Cullin 9 Synthetic Peptide
인간 Cullin 9 단백질의 중심 영역을 기반으로 한 합성 펩타이드로, 항체 차단 실험에 사용됩니다. 고순도 정제된 액상 형태이며 PBS 버퍼에 보관됩니다. 연구용으로만 사용 가능하며 p53 관련 단백질 복합체 연구에 적합합니다.
- 판매단위
- pk
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Thermo Fisher Scientific Human Cullin 9 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human Hrk.
PEP-0354 can be used as a blocking peptide with polyclonal antibody PA5-20277.
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large Parkin-like ubiquitin ligase, has been identified as a cytoplasmic anchor protein in p53-associated protein complexes.
In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promotes cytoplasmic sequestration of p53.
PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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