Thermo Fisher Scientific Phospho-PKC gamma (Thr514) Polyclonal Antibody
PKC gamma의 Thr514 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, 인간 및 설치류 등 다양한 종에 반응합니다. Western blot과 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 뇌 및 신경계 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr514 of human PKCγ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985161 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serves as major receptors for phorbol esters, a class of tumor promoters.
PKC gamma is expressed solely in the brain and spinal cord and is localized to neurons. It plays distinct roles in neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies in mice suggest involvement in neuropathic pain development. Defects in PKC gamma have been associated with spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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