Thermo Fisher Scientific GNAT3 Polyclonal Antibody
GNAT3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry에 사용 가능. Human 시료 반응성. Protein A 및 항원 친화 크로마토그래피로 정제되었으며, 4°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 78–105 amino acids from the central region of human GNAT3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541486 |
Target Information
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.
Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase. Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP, which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium and ultimately release of neurotransmitter.
GNAT3 can functionally couple to taste receptors to transmit intracellular signals: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.
Functions also as lumenal sugar sensors in the gut to control the expression of the Na⁺-glucose transporter SGLT1 in response to dietary sugar, as well as the secretion of GLP-1 and GIP. Thus, GNAT3 may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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