Thermo Fisher Scientific Human Klotho Recombinant Protein, PeproTech
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| 카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
| 100-53-500UG | - | Thermo Fisher Scientific 100-53-500UG Human Klotho Recombinant Protein, PeproTech 500 ug pk | 재고문의 | pk | 2,934,000원 | - | 3,227,400원 | |
| 100-53-250UG | - | Thermo Fisher Scientific 100-53-250UG Human Klotho Recombinant Protein, PeproTech 250 ug pk | 재고문의 | pk | 1,776,000원 | - | 1,953,600원 | |
| 100-53-100UG | - | Thermo Fisher Scientific 100-53-100UG Human Klotho Recombinant Protein, PeproTech 100 ug pk | 재고문의 | pk | 1,080,000원 | - | 1,188,000원 | |
| 100-53-20UG | - | Thermo Fisher Scientific 100-53-20UG Human Klotho Recombinant Protein, PeproTech 20 ug pk | 재고문의 | pk | 311,000원 | - | 342,100원 | |
| 100-53-5UG | - | Thermo Fisher Scientific 100-53-5UG Human Klotho Recombinant Protein, PeproTech 5 ug pk | 재고문의 | pk | 139,000원 | - | 152,900원 | |
Applications
Tested Dilution
Publications
Western Blot (WB)
Assay-dependent
ELISA (ELISA)
Assay-dependent
Functional Assay (Functional)
Assay-dependent
In vitro Assay (IV)
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View 3 publications 3 publications
Miscellaneous PubMed (Misc)
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View 1 publication 1 publication
Product Specifications
Species
Human
Published species
Human, Mouse, Rat
Expression System
CHO cells
Amino acid sequence
EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
Molecular weight
58.6 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by the dose-dependent stimulation of the proliferation of murine NIH-3T3 cells. Recombinant Human Klotho is effective in a concentration range of 0.5-2.0 ug/ml.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
100-53-1MG will be provided as 2 x 500 µg (100-53-500UG).
Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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