Thermo Fisher Scientific Human Amphiregulin Recombinant Protein, PeproTech
Recombinant human Amphiregulin protein produced in E. coli, purity ≥95%. Stimulates proliferation of mouse Balb/c 3T3 cells. 11.3 kDa glycoprotein, lyophilized form, shipped ambient, stored at -20°C. For research use only.
- 카탈로그번호
- 100-55B-xxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human Amphiregulin Recombinant Protein, PeproTech
Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Functional Assay
- Assay-dependent
- View 2 publications
In vitro Assay (IV)
- View 9 publications
Miscellaneous (PubMed)
- View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK |
| Molecular Weight | 11.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Stimulates proliferation of mouse Balb/c 3T3 cells (ED50: 5–10 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF.
The mature secreted form of AR is an 84-amino acid glycosylated polypeptide growth regulator generated by proteolytic processing of a 252-amino acid transmembrane precursor.
Seven different polypeptide ligands derive from distinct genes and bind to the extracellular domain of EGFR: EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and betacellulin.
All of these growth factors contain an EGF-like domain with six evenly spaced cysteine residues forming three loops through disulfide bonds.
AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta.
AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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