Thermo Fisher Scientific Human JMJD1C Synthetic Peptide
인간 JMJD1C의 아미노 말단 20개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. PA5-20804 항체의 블로킹 펩타이드로 사용 가능하며, 히스톤 H3K9 탈메틸화 효소 연구에 적합합니다. 정제된 액상 형태로 -20°C에서 보관합니다.
- 카탈로그번호
- PEP0918
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human JMJD1C Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the amino terminus of human JMJD1C.
PEP-0918 can be used as a blocking peptide with polyclonal antibody PA5-20804.
Target Information
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in nuclear hormone receptor-based transcriptional regulation.
JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells, pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contains bHLH-, AP-1-, and POU5F1-binding sites. Preferential expression of POU5F1 in ES cells, pancreatic islet, and diffuse-type gastric cancer suggests that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in these cells and cancers.
At least three isoforms of JMJD1C are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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