Thermo Fisher Scientific Human JMJD4 Synthetic Peptide
인간 JMJD4의 아미노 말단 17개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20805의 블로킹 펩타이드로 사용 가능하며, 액상 형태로 제공됩니다. PBS 버퍼(pH 7.2, 0.1% BSA) 내에서 -20°C에 보관합니다. 연구용으로만 사용됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of human JMJD4.
PEP-0919 can be used as a blocking peptide with polyclonal antibody PA5-20805.
Target Information
Covalent modification of histones plays a critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones.
A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate.
Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2C H3K9 (both of which demethylate histone 3 at lysine 9).
Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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