Thermo Fisher Scientific Human JMJD1A Synthetic Peptide
인간 JMJD1A의 N-말단 16개 아미노산 서열에 해당하는 합성 펩타이드입니다. PA5-20802 항체의 블로킹 펩타이드로 사용 가능하며, 정제된 액상 형태로 제공됩니다. PBS(pH 7.2, 0.1% BSA) 용액에 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0916
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human JMJD1A.
PEP-0916 can be used as a blocking peptide with polyclonal antibody PA5-20802.
Target Information
JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in the histone code.
It preferentially demethylates mono- and dimethylated H3 Lys-9 residues, with a preference for dimethylated residue, while having weak or no activity on trimethylated H3 Lys-9.
Demethylation of Lys residues generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation by participating in recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation.
It is also involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1, which are required for packaging and condensation of sperm chromatin.
Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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