Thermo Fisher Scientific Human JMJD1A Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the amino terminus of human JMJD1A.
PEP-0916 can be used as a blocking peptide with polyclonal antibody PA5-20802.

Target Information

JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in the histone code.
It preferentially demethylates mono- and dimethylated H3 Lys-9 residues, with a preference for dimethylated residue, while having weak or no activity on trimethylated H3 Lys-9.
Demethylation of Lys residues generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation by participating in recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation.
It is also involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1, which are required for packaging and condensation of sperm chromatin.
Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.