Thermo Fisher Scientific ADORA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, HeLa, HepG2, NIH-3T3
• Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical, and pharmacological analyses have identified four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates receptor subtype-specific physiological processes such as cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.

The A1 adenosine receptor (A1AR) is a glycoprotein that can activate Gi and Go proteins. In intact cells, agonist binding to A1AR inhibits adenylyl cyclase activity and may stimulate phospholipase C, leading to mobilization of intracellular calcium. Activation of potassium channels by A1AR significantly affects the cardiovascular system. A1AR is highly expressed in the brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord, where it modulates neurotransmitter release. In white adipocytes, A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues expressing A1AR include kidney and testis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.