Thermo Fisher Scientific Phospho-CHK2 (Thr387) Polyclonal Antibody
Phospho-CHK2 (Thr387) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응하며, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도(>95%) 제품으로, 1 mg/mL 농도의 액상 형태입니다. DNA 손상 체크포인트 경로 연구용으로 사용됩니다.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution
- 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Chk2 around the phosphorylation site of Threonine 387 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553807 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 62 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers.
CHK2 is activated by DNA damage and phosphorylates modulators of cell cycle control, including tumor suppressor proteins.
It can phosphorylate BRCA1, aiding in survival after DNA damage.
Mutations in CHK2 are associated with Li-Fraumeni syndrome and may predispose to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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