Thermo Fisher Scientific VDR Polyclonal Antibody
VDR 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal antibody로, human에 반응하며 Western blot 및 Flow cytometry에 사용 가능. 액상형으로 0.5 mg/mL 농도, TBS buffer 및 BSA 포함. 연구용으로만 사용.
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Thermo Fisher Scientific VDR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–3 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Internal sequence corresponding to amino acids CGNQDYKYRVSD (aa 288–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2256924 |
Product Specific Information
- Predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone.
The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors, which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.
Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. VDR has been found in intestine, bone, kidney, epidermis, and endocrine immune cells.
Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)₂D₃ interferes with assembly of NFATp/Fos/Jun/DNA complex and subsequent IL-2 gene transcription.
The corresponding gene for the vitamin D receptor is NR1I1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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