Thermo Fisher Scientific TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Monoclonal Antibody (3A4)
TIMP2 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체. 다양한 종에 반응하며 WB, IHC, ICC, Flow 등 다중 응용 가능. 높은 특이성과 재현성을 제공하며, 연구용으로 세포외기질 및 종양 침습 관련 연구에 적합.
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Thermo Fisher Scientific TIMP2 Monoclonal Antibody (3A4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A4 |
| Immunogen | A synthetic peptide from the N-terminus of human TIMP2 protein (aa56–66) (DSGNDIYGNPI) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of the matrix metalloproteinase family, crucial for maintaining connective tissue integrity.
TIMP-2 exhibits high binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2/gelatinase A), and also binds to the active form of 92 kDa Type IV collagenase (MMP-9/gelatinase B).
It inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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