Thermo Fisher Scientific TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Monoclonal Antibody (3A4)
TIMP2 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, WB, IHC, ICC, Flow 등 다양한 응용 가능. 인간 및 여러 종에 반응하며, 단백질 A/G로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Monoclonal Antibody (3A4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A4 |
| Immunogen | A synthetic peptide from the N-terminus of human TIMP2 protein (aa56–66) (DSGNDIYGNPI) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of the matrix metalloproteinase family, important for maintaining connective tissue integrity.
TIMP-2 binds both latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2, gelatinase A) and also the active form of 92 kDa Type IV collagenase (MMP-9, gelatinase B).
It inhibits proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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