Thermo Fisher Scientific PDGFRB Polyclonal Antibody
PDGFRB 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. 비결합(Unconjugated) 형태이며, 1 mg/mL 농도의 액상 제품입니다. 항원 회복 시 citrate buffer(pH 6.0) 사용 권장. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 14 amino acid peptide from extracellular domain of human PDGFRB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage store at -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2550445 |
Product Specific Information
- In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
- Percent identity with other species by BLAST analysis:
- 100%: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Rabbit, Pig
- 93%: Mouse, Rat, Elephant, Horse
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The receptor can form homodimers or heterodimers with PDGFRA depending on the bound ligand. The PDGFRB gene is located on chromosome 5, near the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all of which may be involved in the 5-q syndrome.
A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with ETV6 results in a chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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