Thermo Fisher Scientific Phospho-Jak2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (Jak2Y10071008-PB6)
인간 JAK2 단백질의 Tyr1007/1008 인산화 부위를 인식하는 재조합 토끼 단일클론 항체입니다. Flow Cytometry에 적합하며, 다양한 형광 접합 형식(APC, FITC, PE)으로 제공됩니다. 고순도 Protein A/G 정제, 안정적인 액상 형태로 연구용에 최적화되어 있습니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Jak2Y10071008-PB6 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.10% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897130 |
Additional Formats
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs can lead to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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