Thermo Fisher Scientific ACE2/Angiotensin I Converting Enzyme 2 Recombinant Rabbit Monoclonal Antibody (ACE2/8748R)
인간 ACE2 단백질을 인식하는 재조합 토끼 단클론 항체. IHC(PFA 고정) 및 ELISA에 사용 가능. HEK293 세포에서 발현된 IgG, kappa 형식의 항체로, 단백질 A/G로 정제됨. 심혈관, 신장, 바이러스 수용체 연구에 적합.
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Applications
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ACE2/8748R |
| Immunogen | Recombinant fragment (around aa705–805) of human ACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to the heart, kidney, and testis. ACE2 has also been identified as a functional receptor for the SARS coronavirus. Its normal function is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. Lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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