Thermo Fisher Scientific Calpain 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human CAPN1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Calpain 1,uniProtId:P07384-1,ncbiNodeId:9606,antigenRange:20-330,antigenLength:714,antigenImageFileName:PA5-87524_Calpain_1_P07384-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87524_Calpain_1_P07384-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.04 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804223

Product Specific Information

Immunogen sequence: KQRARELGLG RHENAIKYLG QDYEQLRVRC LQSGTLFRDE AFPPVPQSLG YKDLGPNSSK TYGIKWKRPT ELLSNPQFIV DGATRTDICQ GALGDCWLLA AIASLTLNDT LLHRVVPHGQ SFQNGYAGIF HFQLWQFGEW VDVVVDDLLP IKDGKLVFVH SAEGNEFWSA LLEKAYAKVN GSYEALSGGS TSEGFEDFTG GVTEWYELRK APSDLYQIIL KALERGSLLG CSIDISSVLD MEAITFKKLV KGHAYSVTGA KQVNYRGQVV SLIRMRNPWG EVEWTGAWSD SSSEWNNVDP YERDQLRVKM E; Positive Samples: SW480, A-549, BT-474, MCF-7, Jurkat; Cellular Location: Cell membrane, Cytoplasm

Target Information

The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.