Thermo Fisher Scientific TERT Recombinant Rabbit Monoclonal Antibody (5C11)
인간 TERT 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC(P) 및 ELISA에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 1 mg/mL 농도로 제공. 세포 노화 및 암 연구용으로 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5C11 |
| Immunogen | A synthesized peptide derived from human TERT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Wet ice |
| RRID | AB_3092787 |
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by the TERT gene, and an RNA component serving as the template for telomere repeat synthesis. Telomerase expression is typically repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence. Deregulation of telomerase expression in somatic cells may contribute to oncogenesis. Studies in mice suggest telomerase also plays a role in chromosomal repair through de novo synthesis of telomere repeats at double-stranded breaks. Alternative splicing of TERT results in multiple isoforms, some of which have undetermined full-length sequences, and may regulate telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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