Thermo Fisher Scientific RET Recombinant Rabbit Monoclonal Antibody (8D12)
RET 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Flow Cytometry와 ELISA에 적합합니다. HEK293 세포에서 발현되며, PBS/glycerol 완충액에 보관됩니다. 신경능선 발달 및 종양 관련 RET 신호 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1:20–1:200 |
| ELISA (ELISA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8D12 |
| Immunogen | A synthesized peptide derived from human Ret |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092478 |
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation. Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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