Thermo Fisher Scientific ABCA1 Polyclonal Antibody
ABCA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow 등 다양한 응용에 사용 가능. 인간 및 여러 동물 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 | |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| Flow Cytometry (Flow) | 1:400 | |
| Immunoprecipitation (IP) | 1:10–1:500 | |
| ChIP assay (ChIP) | Assay-dependent | |
| Gel Shift (GS) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Hamster, Human, Mustelid, Mouse, Pig, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1100–1300 of Human ABCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2257654 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by absence of plasma HDL and abnormal cholesterol ester deposition.
ABCA1 mediates apo-A1–associated export of cholesterol and phospholipids from the cell.
It is expressed on the plasma membrane and Golgi complex, regulated by cholesterol flux.
Cholesterol flux regulation between HDL and macrophages involves competitive interaction between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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