Thermo Fisher Scientific PHF17 Polyclonal Antibody
PHF17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. WB, IHC(P), ICC/IF 등에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JADE1 (Accession Q6IE81), corresponding to amino acid residues S681–N731 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854100 |
Product Specific Information
This antibody detects endogenous levels of total PHF17.
Target Information
PHF17 acts as a scaffold subunit of some HBO1 complexes with histone H4 acetyltransferase activity. It directs KAT7/HBO1 specificity toward histone H4 acetylation (H4K5ac, H4K8ac, H4K12ac), regulating DNA replication initiation. It may also promote acetylation of nucleosomal histone H4 by KAT5. PHF17 promotes apoptosis, may act as a renal tumor suppressor, and negatively regulates canonical Wnt signaling, cooperating with NPHP4 in this function. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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