Thermo Fisher Scientific CDK2 Polyclonal Antibody
CDK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합. Human 및 Mouse 반응성, 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CDK2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 248 and 298 of human cyclin-dependent kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Golden hamster
Target Information
CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed to CyclinO. CyclinO, a specific isoform of the UNG gene, is localized exclusively in the nucleus and exhibits uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during the G1 phase and turnover occurs throughout the cell cycle. Cyclin A–CDK2 levels peak at the G1/S transition and associate with DNA in the replication initiation complex. Rb protein acts as a substrate for CDK2–Cyclin E and/or CDK2–Cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1, S, and G2 phases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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