Thermo Fisher Scientific TFAM Polyclonal Antibody
Rabbit polyclonal antibody against TFAM for detecting mitochondrial transcription factor A in human and mouse samples. Validated for Western blot. Affinity purified, liquid form, stored at -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of mouse TFAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691098 |
Product Specific Information
This target displays homology in the following species:
- Mouse: 100%
- Rabbit: 77%
- Rat: 93%
Target Information
Mitochondrial transcription factor A (TFAM) is a crucial protein encoded by nuclear genes but transported to mitochondria, where it maintains and regulates mitochondrial DNA (mtDNA). It controls mtDNA replication and transcription, ensuring proper mitochondrial function. TFAM contains an LC3 interacting region (LIR) motif that binds autophagy proteins such as LC3, supporting the autolysosomal pathway to remove leaked mtDNA and limit inflammation.
TFAM expression varies across tissues, affecting mitochondrial function. High TFAM levels can repress mtDNA expression in skeletal muscle, leading to oxidative phosphorylation (OXPHOS) deficiencies, while in cardiac tissue, balanced TFAM-to-mtDNA ratios preserve OXPHOS capacity. TFAM is essential for mitochondrial genome packaging, stability, and replication, with disruptions linked to neurodegeneration and other mtDNA-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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