Thermo Fisher Scientific STAT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Dog: 92%; Guinea Pig: 85%; Horse: 92%; Human: 85%; Mouse: 100%; Rabbit: 92%; Rat: 93%

Target Information

STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. It regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. STAT1 plays an important role in mediating cell viability in response to different stimuli and pathogen exposure.

The STAT1 gene is located on chromosome 2 and is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many genes. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by multiple ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.