Thermo Fisher Scientific Phospho-FAK (Ser843) Polyclonal Antibody
FAK 단백질의 Ser843 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western Blot 및 Immunocytochemistry에 적합하며, 인간·생쥐·랫트 시료에 반응. 고순도(1 mg/mL) 액상 형태로 −20°C 보관.
- 카탈로그번호
- PA5104966
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PTK2 (Accession Q05397), corresponding to amino acid residues around phosphorylated Ser843 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816439 |
Product Specific Information
This antibody detects endogenous levels of FAK only when phosphorylated at Serine 843.
Target Information
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. It plays a crucial role in cell spreading, differentiation, migration, cell death, and acceleration of the G1–S phase transition. FAK localizes to focal adhesions via its C-terminal tail, mediating cell–matrix interactions through integrin receptors. Tyrosine phosphorylation of FAK increases upon integrin engagement with fibronectin, promoting association with Grb2 and c-Src, and activating ERK2 MAP kinase pathways. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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