Thermo Fisher Scientific Phospho-PKC zeta (Thr410) Polyclonal Antibody
PKC zeta의 Thr410 인산화를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성 검증. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PRKCZ (Accession Q05513), corresponding to amino acid residues around phosphorylated Thr410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816440 |
Product Specific Information
This antibody detects endogenous levels of PKC zeta only when phosphorylated at Threonine 410.
Target Information
The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC zeta plays a key regulatory role in various cellular functions including cell growth and differentiation, gene expression, hormone secretion, and membrane function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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