Thermo Fisher Scientific MBNL1 Polyclonal Antibody
Thermo Fisher Scientific의 MBNL1 Polyclonal Antibody는 인간 유래 단백질에 반응하는 토끼 IgG 항체로, WB, ICC/IF, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA529541
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 81–326 of Human Muscleblind-like 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547017 |
Product Specific Information
- Recommended positive control: U87-MG
- Predicted reactivity: Mouse (100%), Rat (91%), Chicken (98%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases: ERbB2, ERbB3, and ERbB4.
EGFR is a transmembrane receptor; binding of ligands such as EGF and TGF-alpha leads to dimerization and autophosphorylation of tyrosine residues. This activation triggers downstream signaling cascades including Ras–ERK, PI3K–Akt, Jak–STAT, and PKC pathways, promoting cell growth and proliferation.
Phosphorylation at Y1086 enables GRB2 binding and MAPK pathway activation. EGFR mutations are linked to lung cancer, and overexpression is associated with poor prognosis in various tumors including those of the head, neck, brain, bladder, stomach, breast, lung, and others.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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