Thermo Fisher Scientific FGFR1 Monoclonal Antibody (2E12)
FGFR1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단일클론 항체입니다. Western blot 및 ELISA에 적합하며, 인간 시료 반응성이 검증되었습니다. 단백질 발현 및 신호전달 연구용으로 사용됩니다. 보존제 없이 PBS 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E12 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family, consisting of four membrane-spanning tyrosine kinases (FGFR1–4) that serve as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
The FGF receptor family is involved in key biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, producing multiple isoforms expressed in various tissues during development and in adults.
Mutations or aberrations in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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