Thermo Fisher Scientific UBE2V2 Polyclonal Antibody
Thermo Fisher Scientific의 UBE2V2 폴리클로날 항체는 Human, Mouse, Rat 시료에 반응하며 Western Blot 및 IHC(Paraffin) 적용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. 연구용으로 DNA 복구 및 단백질 유비퀴틴화 연구에 활용됩니다.
- 카탈로그번호
- PA577091
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human UBE2V2 (amino acids 1–145) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720818 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The differentiation and activation of monocytes (MO) and monocytic cells are modulated by 1α,25-dihydroxyvitamin D3 (Vitamin D3). Using mRNA Differential Display technology, a gene induced in human monocytes cultured with Vitamin D3 was identified. This gene encodes a 16.5 kDa protein structurally homologous to yeast MMS2p and human CROC-1, defining the conserved Ubc-like protein family.
UBE2V2 (also known as MMS2) is required, along with Ubc13, for RAD6/RAD18-dependent postreplicative DNA repair and plays a central role in assembling K63-linked polyubiquitin chains. These chains act as novel signals in DNA repair and IκBα kinase activation. Crystal structure analysis confirms that the Mms2/Ubc13 heterodimer is essential for DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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