Thermo Fisher Scientific GPR120 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Positive test controls include:

• HT-29
• BxPC-3
• RAW264.7
• Mouse large intestine
• Rat large intestine
• Rat small intestine

Immunogen sequence:
NPILYNMTLC RNEWKKIFCC FWFPEKGAIL TDTSVKRNDL SIISG

Target Information

An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
Activating ligands induce conformational changes leading to signaling via G-proteins and downstream effectors.
Negative regulation of GPCRs plays a crucial role in cellular physiology and is a key area in pharmacological research.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.