Thermo Fisher Scientific Bora Recombinant Rabbit Monoclonal Antibody (10H2L1)

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, Bovine, and Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire

Target Information

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), a centrosome-associated serine/threonine kinase regulating centrosome maturation, bipolar spindle assembly, and chromosome segregation during mitosis.
Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2-dependent manner. Activation of Cdc2 releases Bora into the cytoplasm, enabling it to bind and activate ARK-1.
PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry.
Mutations in Bora result in multipolar spindles similar to those observed when ARK-1 function is blocked. Thus, the ARK1–Bora–PLK1 regulatory circuit elucidates a key mechanism in mammalian cell cycle regulation.
At least three isoforms of Bora are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: 702148_Bora_Q6PGQ7-1_Rabbit.svg, 702148_Bora_Q6PGQ7-1_Rabbit_PDP.jpeg)