Thermo Fisher Scientific DPYSL5 Monoclonal Antibody (2D10)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MLANSASVRI LIKGDKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV DAYEKCRGLA DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVLHA CKDIGAIARV HAENGELVAE GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVIWE RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDT VYKKLVQREK TLKVRGVDRT PYLGDVAVVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPERASA RILAPPGGRS SGIW

Target Information

The collapsin response mediator protein (CRMP) family (also referred to as ULIP6) are neurologic proteins that play key roles in growth cone guidance during neural development.
CRMP5 has relatively low sequence homology with other CRMP members and is expressed in the developing nervous system with peak expression during the first postnatal week.
Elevated levels of autoantibody to CRMP5 have been linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms.
Autoimmunity against CRMP5 expression (predominantly N-terminal epitopes) is being investigated as an oncological marker in the respiratory system and thymus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.