Thermo Fisher Scientific WT1 Polyclonal Antibody
WT1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 최적화되어 있으며 인간 시료에 반응. 합성 펩타이드 면역원 사용, 고순도 정제 및 안정적 액상 형태로 제공. 연구용으로만 사용 가능.
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- PA518548
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- pk
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Thermo Fisher Scientific WT1 Polyclonal Antibody
Applications
- Western Blot (WB): 1–3 µg/mL
- Tested in Peptide ELISA (antibody detection limit dilution: 1:32,000)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QDPASTCVPEPASQH) corresponding to the N-terminus amino acids of WT1 (aa 7–21) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981452 |
Target Information
The Wilms Tumor 1 (WT1) gene encodes one of the WPP domain-interacting proteins required for RanGAP nuclear envelope association in root tip cells.
Ran GTPase is essential for nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly.
The cytoplasmic RanGTPase activating protein (RanGAP) helps establish a functional RanGTP/RanGDP gradient across the nuclear envelope.
In Arabidopsis thaliana, RanGAP association requires CC-TMD and WPP domain-interacting proteins (WIPs). WT1 and WIT2 are a second family of CC-TMD proteins distinct from WIPs, crucial for RanGAP nuclear envelope association in root tip cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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