Thermo Fisher Scientific NOLA1 Polyclonal Antibody
Western blot, IHC, ICC 등 다양한 응용에 적합한 Rabbit Polyclonal NOLA1 항체. Human, Mouse, Rat 반응성. Affinity chromatography로 정제된 1 mg/mL 액상 제품으로, PBS/glycerol buffer에 보관. 리보솜 생합성과 텔로미어 유지 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAR1 (Accession Q9NY12), corresponding to amino acid residues A135–R185 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818734 |
Product Specific Information
Antibody detects endogenous levels of total NOLA1.
Target Information
NOLA1 is required for ribosome biogenesis and telomere maintenance. It is part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This process involves the isomerization of uridine so that the ribose attaches to C5 instead of N1. Each rRNA can contain up to 100 pseudouridine (ψ) residues, which may stabilize rRNA conformation. NOLA1 may also be necessary for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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