Thermo Fisher Scientific IL-17f Polyclonal Antibody
Thermo Fisher Scientific의 IL-17F Polyclonal Antibody는 마우스 IL-17F를 인식하는 고감도 항체로, WB, ICC/IF, ELISA에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 비보존제 PBS 버퍼에 동결건조 형태로 제공됩니다. 염증성 사이토카인 연구용으로 최적화된 제품입니다.
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Thermo Fisher Scientific IL-17F Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| ELISA | 0.1–0.4 µg/mL (Detection), 0.2–0.8 µg/mL (Capture) |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse IL-17F (Arg29–Ala153) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607087 |
Product Specific Information
- In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant human IL-17F, mouse IL-17, IL-17B, IL-17C, IL-17D, and IL-17E is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
IL-17F (Interleukin 17F, CTLA-8) is a cytokine belonging to the IL-17 family, produced by activated T cells, mast cells, and basophils. It plays a key role in allergic airway inflammation and induces cytokines, chemokines, and adhesion molecules in various cell types including bronchial epithelial and endothelial cells.
IL-17F acts through the IL-17R receptor to recruit monocytes and neutrophils, enhancing chemokine production. It also stimulates TNF-α, IL-1β, IL-6, and IL-8 expression, contributing to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
IL-17F is secreted as a homodimer or heterodimer with IL-17A, and is highly expressed by activated effector memory T cells. It has been shown to inhibit angiogenesis and induce IL2, TGFB1/TGFB, and MCP-1 production in endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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