Thermo Fisher Scientific Phospho-RUNX2 (Ser275) Polyclonal Antibody
RUNX2의 Ser275 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RUNX2 (Accession Q13950), corresponding to amino acid residues around phosphorylated Ser275 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817070 |
Product Specific Information
This antibody detects endogenous levels of RUNX2 only when phosphorylated at Ser275.
Target Information
RUNX2 is a nuclear protein and a member of the RUNX family of transcription factors with a Runt DNA-binding domain. It is essential for membranous and endochondral bone formation, regulating osteoblastic differentiation and skeletal morphogenesis. RUNX2 also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It binds DNA both as a monomer and more strongly as part of a heterodimeric complex. RUNX2 plays a critical role in increasing TGFBR1 expression by osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific gene expression. Mutations in RUNX2 can cause bone development disorders such as cleidocranial dysplasia (CCD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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