Thermo Fisher Scientific Phospho-RUNX2 (Ser28) Polyclonal Antibody
RUNX2 단백질의 Ser28 인산화 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능하며, 인간, 마우스, 랫트에 반응합니다. 고순도 정제 및 -20°C 보관 안정성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RUNX2 (Accession Q13950), corresponding to amino acid residues around phosphorylated Ser28. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817071 |
Product Specific Information
This antibody detects endogenous levels of RUNX2 only when phosphorylated at Ser28.
Target Information
RUNX2 is a nuclear protein and a member of the RUNX family of transcription factors, possessing a Runt DNA-binding domain. It is essential for membranous and endochondral bone formation, regulating osteoblastic differentiation and skeletal morphogenesis. RUNX2 also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It binds DNA as a monomer or more efficiently as part of a heterodimeric complex. RUNX2 plays a critical role in increasing TGFBR1 expression by osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific gene expression. Mutations in RUNX2 can lead to bone development disorders such as cleidocranial dysplasia (CCD).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-105643_RUNX2_Q13950-1_Rabbit.svg, PA5-105643_RUNX2_Q13950-1_Rabbit_PDP.jpeg)
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