Thermo Fisher Scientific Cofilin Monoclonal Antibody (AF2C2)
Cofilin 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, ELISA에 사용 가능. 액상 형태로 제공되며 1 mg/mL 농도. 세포골격 조절 연구 및 세포 형태 연구에 적합. 권장 양성 대조군은 Jurkat 세포.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 4 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AF2C2 |
| Immunogen | Recombinant human protein purified from E. coli (His-cofilin) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2538691 |
Product Specific Information
A suggested positive control for this product is Jurkat cells.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics, which is important for normal progress through mitosis and cytokinesis. Cofilin plays a role in regulating cell morphology and cytoskeletal organization. It is required for the up-regulation of atypical chemokine receptor ACKR2 from the endosomal compartment to the cell membrane, enhancing chemokine uptake and degradation. Additionally, it is essential for neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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