Thermo Fisher Scientific PGP9.5 Monoclonal Antibody (AF3F8)

Applications

Western Blot (WB)

• Tested Dilution: 0.5 µg/mL

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is SK-N-MC cells.

Target Information

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12). PGP9.5 exhibits ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.

PGP9.5 is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression is associated with non-small cell lung cancer, while decreased expression is linked to Huntington and Alzheimer diseases. Its presence in cellular inclusions makes it a useful neuronal marker for studying neurodegenerative disorders such as Parkinson’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.