Thermo Fisher Scientific Laminin, gamma 1 (LAMC1) Monoclonal Antibody (A5)
Laminin gamma 1 (LAMC1) 단백질을 인식하는 Rat 모노클로날 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. Protein A/G로 정제된 액상 형태이며, 보존제가 포함되지 않음. 연구용으로만 사용.
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Thermo Fisher Scientific Laminin, gamma 1 (LAMC1) Monoclonal Antibody (A5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1.0 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A5 |
| Immunogen | Murine EHS laminin preparation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes are polymers of Laminins stabilized by Type IV Collagen networks, Nidogen, and proteoglycans. They are found under epithelial layers, around blood vessel endothelium, and surrounding muscle, peripheral nerve, and fat cells. Laminins influence cell proliferation, migration, gene expression, and tissue architecture.
Each Laminin is a heterotrimer composed of alpha, beta, and gamma chain subunits that undergo secretion and incorporation into the extracellular matrix. Laminins can self-assemble, interact with other matrix macromolecules, and mediate cell interactions through Integrins, dystroglycan, and Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues producing basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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