Thermo Fisher Scientific mPR alpha Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF YFRTLFQQHN EA

Highest antigen sequence identity to the following orthologs:

• Mouse: 78%
• Rat: 81%

Target Information

The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways.

Three distinct groups, designated α, β, and γ, comprise this gene family.

• mPRα (PAQR7):
  Consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. Expressed in ovary, testis, placenta, uterus, and bladder.

• mPRβ (PAQR8):
  Consists of eight putative transmembrane regions and an intracellular N-terminus containing a leucine-rich motif. A 354 amino acid protein (~40 kDa), expressed in brain and spinal cord.

Both mPRα and mPRβ may be G protein-coupled receptors involved in oocyte maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.