Thermo Fisher Scientific mPR alpha Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human mPR alpha를 인식합니다. Western blot, IHC(P), ICC/IF 등 다양한 응용에 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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- PA561376
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human mPR alpha. Recombinant protein control fragment (Product # RP-99833) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644087 |
Product Specific Information
Immunogen sequence:
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF YFRTLFQQHN EA
Highest antigen sequence identity to the following orthologs:
- Mouse: 78%
- Rat: 81%
Target Information
The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways.
Three distinct groups, designated α, β, and γ, comprise this gene family.
mPRα (PAQR7):
Consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. Expressed in ovary, testis, placenta, uterus, and bladder.mPRβ (PAQR8):
Consists of eight putative transmembrane regions and an intracellular N-terminus containing a leucine-rich motif. A 354 amino acid protein (~40 kDa), expressed in brain and spinal cord.
Both mPRα and mPRβ may be G protein-coupled receptors involved in oocyte maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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