Thermo Fisher Scientific SOCS2 Recombinant Rabbit Monoclonal Antibody (ARC1470)
SOCS2 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ICC, ELISA 등에 사용 가능. 인간, 생쥐, 랫트 시료에 반응하며, HEK293 발현 시스템에서 생산된 재조합 항체. 고순도 Affinity Chromatography 정제 및 안정한 PBS/glycerol buffer로 보관 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1470 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–198 of human SOCS2 (NP_001257400.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.0 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849676 |
Product Specific Information
Immunogen sequence:
MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG LPLPTRLKDY LEEYKFQV
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, and interferon (IFN)-gamma.
The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), suggesting its role in regulating IGF1R-mediated cell signaling.
Knockout studies in mice indicate a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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