Thermo Fisher Scientific UCH37 Polyclonal Antibody
UCH37 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 고순도 항원 친화 크로마토그래피로 정제됨. 인간 반응성, 다양한 종에서 예측 반응성 확인. 연구용 전용 제품.
- 카탈로그번호
- PA585693
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human UCHL5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792832 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (83%), Xenopus laevis (90%), Pig (98%), Chicken (89%), Bovine (98%)
- Positive Control: 293T
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, suggesting potential therapeutic interest. Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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